Rejeunesse Shape: Pure Polycaprolactone (PCL) Biostimulator for Deep Structural Rejuvenation & Collagen Induction

Rejeunesse Shape, manufactured by **Hugel Inc.** (South Korea), is a **biostimulatory dermal filler** utilizing **100% polycaprolactone (PCL) microspheres** suspended in a carboxymethylcellulose (CMC) gel carrier. Presented as a **1.0 ml sterile lyophilized powder in a vial**, it requires **reconstitution with 3.0 ml of sterile saline (0.9% NaCl)**. Unlike immediate volumizing fillers, Rejeunesse Shape focuses on **long-term tissue regeneration**, stimulating neocollagenesis and neoelastogenesis to improve skin thickness, elasticity, and structural support over time.https://skin-reboot.com/

**Core Technology & Mechanism:**
* **Pure PCL Microspheres:** Contains **approximately 70% PCL microspheres by volume** (size ~ 20-50 microns). PCL is a biocompatible, semi-crystalline polymer known for its **slow, predictable biodegradation** (up to 24-36 months).
* **CMC Gel Carrier:** Provides immediate volume upon injection, facilitating placement and temporarily occupying space while the biostimulation process begins. The CMC degrades within weeks.
* **Collagen Induction:** The PCL microspheres act as a persistent scaffold, inducing a controlled foreign body reaction. This stimulates fibroblasts to produce **new Type I collagen and elastin fibers** over several months, gradually thickening the dermis/subcutaneous tissue and improving structural integrity.
* **Delayed Onset, Long Duration:** Results are **not immediate**. Effects develop progressively over **3-6 months** as new collagen forms, with improvements typically lasting **24+ months**. The CMC carrier provides minimal transient volume.

**Primary Indications:**
* **Skin Laxity & Quality Improvement:** Enhancing skin thickness, firmness, and elasticity in areas prone to sagging (lower face, neck, décolletage, dorsal hands).
* **Deep Volume Restoration & Structural Support:** Rebuilding foundational support in areas like the midface (cheeks), temples, jawline, and chin, especially where structural loss underlies visible aging.
* **Moderate to Severe Nasolabial Folds (NLFs) & Marionette Lines:** Correcting deep folds requiring underlying structural reinforcement beyond simple filling.
* **Hand Rejuvenation:** Correcting volume loss, prominent tendons/veins, and improving skin quality on the dorsum of the hands.
* **Overall Facial Contouring & Lifting:** Providing subtle lifting and definition through tissue regeneration.

**Key Administration Considerations:**
* **Reconstitution:** **Mandatory.** Reconstitute with **3.0 ml sterile saline only** (no lidocaine in vial; local anesthesia required separately). Vigorous shaking for 5+ minutes is essential to create a homogenous suspension. Allow to hydrate (15-30 mins).
* **Anesthesia:** **Essential.** Requires nerve blocks or local infiltration with lidocaine/epinephrine *before* injection.
* **Technique:** **Deep Subcutaneous/Supraperiosteal Placement:** **Critical.** Must be injected deep using a **blunt cannula (25G, 38-50mm recommended)**. Needles carry high vascular occlusion risk. Techniques: Fanning, linear threading, multiple retrograde linear threads. **Aspiration mandatory if needles used (not recommended).**
* **Depth:** **Deep subcutaneous fat or supraperiosteal plane.** Superficial injection causes visible nodules/granulomas.
* **Volume:** Moderate volumes per session (e.g., 1-2 vials per NLF/midface). Gradual improvement; touch-ups after 3+ months.
* **Post-Treatment:** **Mandatory Massage:** Vigorous massage (e.g., 5 mins, 5x/day, 5-7 days) is crucial to ensure even particle distribution and minimize nodule risk. Significant swelling (“watermelon effect”), bruising, tenderness expected for 1-2 weeks. Avoid pressure otherwise.
* **Results Timeline:** No immediate filler effect. Progressive collagen stimulation begins ~4-8 weeks, peaks at 3-6 months, lasts 24+ months.
* **Safety:**
* **Critical Risks:** **Vascular Occlusion/Embolism** (potentially catastrophic – deep cannula technique vital). **Nodules/Granulomas** (late-onset, weeks/months post-injection – proper depth and massage are non-negotiable). **Asymmetry.**
* **Contraindications:** Active infection, bleeding disorders, hypersensitivity to components.
* **Regulatory Status:** **CE marked** (Europe/international). **Not FDA-approved in the USA.**
* **Prescription:** Prescription medical device.

Rejeunesse Shape requires advanced injection expertise, strict adherence to deep cannula placement, and diligent post-procedure massage. It offers powerful, long-term structural rejuvenation for patients seeking collagen-based correction beyond traditional HA fillers.CONTACT US

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