Replengen Deep

Replengen Deep: High G’ Monophasic HA Filler for Structural Volumization & Contouring

Replengen Deep, manufactured by **Hugel Inc.** (South Korea), is a **high viscosity, high G-prime (G’) monophasic hyaluronic acid (HA) dermal filler** specifically engineered for **deep structural volumization, lifting, and contouring** in areas requiring significant tissue support. Presented in a **1.0 ml prefilled syringe**, it contains a **high concentration of cross-linked HA (24 mg/ml)** and features **integrated 0.3% lidocaine HCl** for enhanced patient comfort during injection. Replengen Deep prioritizes lifting capacity and projection over subtlety.https://skin-reboot.com/

**Core Technology & Properties:**
* **High G-Prime Monophasic NASHA Gel:** Features a uniform, highly cross-linked HA matrix (Crystal Matrix Technology™) with **exceptional elasticity (high G’) and viscosity**. This provides superior resistance to deformation, enabling significant lifting force and projection for sculpting facial contours and restoring deep volume deficits.
* **High Cohesivity:** Particles bind cohesively, ensuring structural integrity, minimizing migration risk, and providing stable, predictable volumization. Ideal for foundational placement.
* **Integrated Anesthetic:** **0.3% lidocaine HCl** is uniformly dispersed within the gel, significantly reducing injection pain without compromising rheology.
* **Optimized for Deep Placement:** Engineered for stability and longevity when injected into the deep dermis, subcutaneous tissue, or supraperiosteal plane. Less suitable for superficial lines.
* **Slow Degradation:** Designed for extended duration due to high cross-linking density.

**Mechanism of Action:**
1. **Deep Volumization & Lifting:** Restores significant lost volume in deep dermal/subcutaneous/supraperiosteal layers (cheeks, chin, jawline, temples), providing immediate projection and structural support.
2. **Contour Definition & Sculpting:** Defines and enhances facial contours and angles (cheekbones, jawline, chin projection, temporal hollows).
3. **Fold Correction:** Addresses **moderate to severe nasolabial folds (NLFs)**, marionette lines, and pre-jowl sulcus by providing deep foundational support and lifting.
4. **Hydration:** HA binds water, contributing to tissue hydration.

**Primary Indications:**
* **Cheek Augmentation & Volumization:** Restoring significant midface volume loss and enhancing malar projection.
* **Chin Augmentation:** Enhancing chin projection and contour.
* **Jawline Definition & Contouring:** Defining the mandibular border and correcting pre-jowl sulcus.
* **Temple Restoration:** Correcting temporal hollowing/volume loss.
* **Moderate to Severe Nasolabial Folds (NLFs):** Providing deep structural support and effacement.
* **Marionette Lines & Pre-jowl Sulcus:** Correcting oral commissure descent and mandibular contour loss.
* **Facial Sculpting:** Overall enhancement of facial bone structure and contours.

**Key Administration Considerations:**
* **Ready-to-Use:** No reconstitution required. **Integrated 0.3% lidocaine.**
* **Anesthesia:** Integrated lidocaine provides pain relief. Nerve blocks/local infiltration often still required due to viscosity and depth.
* **Technique:**
* **Needles:** Suitable for **sharp needles (25-27G)** for precise bolus placement in deep planes. Requires high injection force. **Aspiration mandatory.**
* **Cannulas:** Compatible with **blunt cannulas (22-25G, 50mm recommended)** for safer fanning/threading in vascular areas (e.g., NLFs, cheeks). Lower force needed.
* **Methods:** Bolus (supraperiosteal/deep subQ), fanning (deep subQ), linear threading (deep dermal/subQ). Avoid superficial placement.
* **Depth:** **Critical: Mid-to-Deep Dermis, Subcutaneous, or Supraperiosteal Plane.** Superficial injection risks visibility, Tyndall effect (if too shallow in dermis), or vascular compromise.
* **Volume:** Can handle moderate to larger volumes per session for significant augmentation. Gradual layering possible.
* **Post-Treatment:** Significant swelling, bruising, tenderness, redness common for 1-2 weeks. Avoid pressure/massage.
* **Longevity:** Typically **12-18 months**, varying with area and technique.
* **Safety:**
* **Critical Risks:** **Vascular Occlusion/Embolism** (high risk due to viscosity and deep placement – meticulous aspiration, cannulas preferred, knowledge of anatomy vital). **Nodules/Lumps** (especially if superficial or overcorrection). **Tyndall Effect** if injected too superficially. Granuloma risk (rare). Lidocaine allergy possible.
* **Contraindications:** Active infection, bleeding disorders, hypersensitivity.
* **Regulatory Status:** **CE marked** (Europe/international). **Not FDA-approved in the USA.**
* **Prescription:** Prescription medical device.

Replengen Deep is a powerful tool for experienced injectors seeking high-lift, structural volumization and contouring, demanding precise deep placement techniques and heightened awareness of vascular risks due to its high G’ properties.CONTACT US