POWER COL-TRA

POWER COL-TRA: Dual-Mechanism Collagen Stimulator with Immediate Hyaluronic Acid Volumization

POWER COL-TRA , manufactured by **Hugel Inc.** (South Korea), is an innovative **dual-mechanism injectable** combining **immediate hyaluronic acid (HA) volumization** with **long-term collagen stimulation** using Poly-D,L-lactic acid – Polycaprolactone (PLLA-PCL) copolymer microspheres. Presented as a **1.0 ml lyophilized powder in a prefilled syringe**, it requires **reconstitution with 4 ml of sterile water** (typically with 0.3-0.5 ml of 2% lidocaine for anesthesia). It uniquely addresses both **instant volume correction** and **sustained structural rejuvenation** through tissue regeneration.https://skin-reboot.com/

**Core Technology & Mechanism:**
1. **Immediate Volumization & Hydration:** Contains **20 mg/ml of non-animal stabilized HA (NASHA)**. Upon injection, this HA provides instant volume replacement, fold correction, and skin hydration, acting like a traditional dermal filler.
2. **Stimulated Collagenesis:** Contains **50 mg of PLLA-PCL copolymer microspheres**. These biodegradable particles act as a scaffold, triggering a controlled inflammatory response that stimulates **neocollagenesis and neoelastogenesis** over several months, leading to gradual tissue thickening, tightening, and structural improvement.
3. **Dual-Phase Action:** HA provides immediate cosmetic improvement while the PLLA-PCL works progressively, with results evolving over 3-6 months. The HA component degrades within ~6-9 months, leaving the collagen stimulation to provide long-lasting effects (typically **24+ months**).

**Primary Indications:**
* **Midface Volumization & Contouring:** Restoring cheek volume and projection, addressing age-related deflation.
* **Moderate to Severe Nasolabial Folds (NLFs):** Correcting deep folds requiring both immediate filling and long-term structural support.
* **Marionette Lines & Pre-jowl Sulcus:** Improving oral commissure descent and mandibular contour.
* **Skin Laxity & Quality Improvement:** Enhancing skin thickness, elasticity, and overall texture in areas prone to sagging (e.g., lower face, jawline).
* **Overall Facial Rejuvenation:** Providing comprehensive improvement combining volume restoration with tissue tightening.

**Key Administration Considerations:**
* **Reconstitution:** **Mandatory.** Requires reconstitution with 4 ml sterile water (or saline), ideally mixing with lidocaine. Vigorous shaking for 5+ minutes is crucial for homogeneous suspension. Allow to hydrate (15-30 mins).
* **Anesthesia:** **Essential.** Requires nerve blocks/local infiltration; lidocaine is typically added during reconstitution.
* **Technique:** **Deep Dermal/Subcutaneous Placement:** Via **blunt cannula (25G, 38-50mm)** strongly preferred over needles (high vascular risk). Requires **bolus or fanning technique** in multiple planes (deep subcutaneous to mid-deep dermal). **Aspiration mandatory** if needles used.
* **Depth:** **Deep dermis or subcutaneous fat.** Superficial injection causes visible nodules.
* **Volume:** Moderate volumes per session; typically requires 1-2 syringes per area. Gradual improvement over months; touch-ups possible after 3+ months.
* **Post-Treatment:** Significant swelling (“watermelon effect”), redness, bruising, tenderness common for 1-2 weeks. Massage protocol often required (e.g., 5 mins, 5x/day, 5 days) to ensure even particle distribution and minimize nodule risk. Avoid pressure otherwise.
* **Results Timeline:** Immediate HA effect, followed by progressive collagen stimulation peaking at 3-6 months, lasting 24+ months.
* **Safety:**
* **Critical Risks:** **Vascular Occlusion/Embolism** (potentially catastrophic – cannulas preferred, aspirate needles). **Nodules/Granulomas** (late-onset, weeks/months post-injection – proper depth, massage, technique vital). **Asymmetry.**
* **Contraindications:** Active infection, bleeding disorders, hypersensitivity to components.
* **Regulatory Status:** **CE marked** (Europe/international). **Not FDA-approved in the USA.**
* **Prescription:** Prescription medical device.

POWER COL-TRA offers a powerful dual-action solution for comprehensive facial rejuvenation, demanding expert technique (deep cannula placement, massage), meticulous reconstitution, and careful patient management due to significant swelling and unique long-term safety considerations.CONTACT US